Daniel Siegwart Laboratory at the University of Texas Southwestern Medical Center

At UT Southwestern, the Siegwart Research Group uses a materials chemistry approach to tackle challenges in cancer therapy and diagnosis.

We are currently focused on 1) the development of improved materials for effective delivery of siRNA, miRNA, mRNA, and CRISPR/Cas therapeutics to manipulate gene expression in tumors; and 2) the discovery of stimuli-responsive cancer imaging probes.  Long-term, we aim to globally understand how the physical and chemical properties of materials affect interactions with biological systems in the context of improving cancer therapies.