Dr. Daniel J. Siegwart
Daniel Siegwart is the W. Ray Wallace Distinguished Chair in Molecular Oncology Research and Professor at the University of Texas Southwestern Medical Center. His research program is focused on developing advanced lipid and polymer based systems with precise control over structure and responsiveness for applications in drug delivery, imaging, genetic diseases, and cancer.
He co-founded ReCode Therapeutics in order to translate UT Southwestern developed nanoparticles for delivery of genetic medicines. ReCode is a biopharmaceutical company developing precision medicines for pulmonary diseases with significant unmet medical need including primary ciliary dyskinesia (PCD) and cystic fibrosis (CF).
2023 – Present: Professor, University of Texas Southwestern Medical Center, Department of Biomedical Engineering, Department of Biochemistry, Simmons Comprehensive Cancer Center
2022 – Present: Director, Program in Genetic Drug Engineering
2022 – Present: Director, Drug Delivery Program in Biomedical Engineering, Department of Biomedical Engineering
2020 – Present: Co-Director of the Chemistry and Cancer Program, Simmons Comprehensive Cancer Center
2018 – 2023: Associate Professor, University of Texas Southwestern Medical Center, Department of Biochemistry, Simmons Comprehensive Cancer Center
2012 – 2018: Assistant Professor, University of Texas Southwestern Medical Center, Department of Biochemistry, Simmons Comprehensive Cancer Center
2008 – 2012: Postdoctoral Fellow, Massachusetts Institute of Technology (MIT), Department of Chemical Engineering, Koch Institute for Integrative Cancer Research (Advisors: Institute Professor Robert Langer and Professor Daniel Anderson)
2003 – 2008: Ph.D. Chemistry, Carnegie Mellon University (CMU), (Advisor: University Professor Krzysztof Matyjaszewski)
1999 – 2003: B.S. Biochemistry, Lehigh University
Awards and Fellowships: Controlled Release Society (CRS) College of Fellows, American Institute for Medical and Biological Engineering (AIMBE) College of Fellows (2022), Howard Hughes Medical Institute (HHMI) Gilliam Fellowship for Advanced Study (adviser-student pair) (2021), Biomaterials Science Emerging Investigator (2019), Young Innovator Award in Nanobiotechnology (2018), American Cancer Society (ACS) Research Scholar (2017), Friends of the Comprehensive Cancer Center Award in Cancer Research (2014), Cancer Prevention and Research Institute of Texas (CPRIT) Scholar Award (2012), National Institutes of Health (NIH) Ruth L. Kirschstein National Research Service Award (NRSA) F32 Postdoctoral Fellowship (2010), National Science Foundation (NSF) East Asia and Pacific Summer Institutes (EAPSI) Fellowship at The University of Tokyo (Advisor: Professor Kazunori Kataoka) (2006), The Joseph A. Solomon Memorial Fellowship in Chemistry (CMU) (2005), Chemistry Department Research Honors (Lehigh) (2003)
Current Lab Members
- Laytonique Bacon
- Pratima Basak, Ph.D.
- Xiaoyan Bian
- Sumanta Chatterjee, Ph.D.
- Zexiang Chen, Ph.D.
- Lukas Farbiak, Ph.D.
- Erick Guerrero
- Lisa Kim
- Minjeong Kim, Ph.D.
- Sang Lee, Ph.D.
- Xizhen Lian, Ph.D.
- William Miller
- Stephen Moore
- Clarissa Pham
- Joshua Robinson
- Eunice Song
- Yehui Sun
- Yun-Chieh Sung, Ph.D.
- Zeru Tian, Ph.D.
- Amogh Vaidya
- Xu Wang, Ph.D.
- Shiying Wu
- Yufen Xiao, Ph.D.
- Kohki Yamada
- Chuhan Zhang, Ph.D.
- Fangyu Zhang, Ph.D.
Lab Alumni
- Jing Hao, Ph.D.
- Postdoc, 2012 – 2014
- Current position: Assistant Professor, George Fox University
- Denise Bamberger
- Visiting graduate student from Johannes Gutenberg–University Mainz, Germany, 2015
- Current position: Boehringer Ingelheim
- Atsushi Nagai, Ph.D.
- Visiting professor, 2015
- Former Position: Assistant Professor, Institute for Molecular Science, Japan
- Current position: Associate Professor, Delft University of Technology, The Netherlands
- Lian Xue, Ph.D.
- Postdoc, 2014 – 2015
- Victor Tieu
- SURF student, summer 2015
- Former position: Undergraduate student, University of California at Berkeley
- Current position: Graduate student, Stanford University
- John Norman
- High school research student, summer 2015
- Current position: Undergraduate student, Texas A&M
- Karina Kinghorn
- Green Fellow and SURF student, 2016
- Former position: Undergraduate student, University of Texas at Dallas
- Current position: Graduate student, University of North Carolina at Chapel Hill
- Siva Venigalla
- Khorana Bose scholar, summer 2016
- Current position: Undergraduate student, Indian Institute of Technology, Madras
- Current position: Graduate student, UT Southwestern Medical Center
- Bethanie Abram
- STARS high school research student, summer 2016
- Former position: High school student, Irving High School
- Current position: Undergraduate student, Texas A&M
- Gino Occhialini
- QP SURF student, summer 2016
- Former position: Undergraduate student, University of Texas at Dallas
- Current position: Graduate student, MIT
- Sergio Barrios
- SURF BUILD Scholar, summer 2016
- Former position: Undergraduate student, University of Texas at El Paso
- Current position: Graduate student, Rice University
- Jonathan Minnig
- Green Fellow and Research Technician, 2015 – 2016
- Current position: Research Technician, UT Southwestern
- Yunfeng Yan, Ph.D.
- Postdoc, 2012 – 2016
- Current position: Professor, Zhejiang University of Technology
- Kels Kaiser
- Research Technician, 2016 – 2017
- Current position: Clinical Research Coordinator, Radiation Oncology, UT Southwestern
- Petra Kos, Ph.D.
- Postdoc, 2014 – 2018
- Current position: Life Science Specialist, L.E.K. Consulting
- Jason Miller, Ph.D.
- Graduate student, 2012 – 2018
- Current position: Project Manager, OncoNano
- Sussana Elkassih, Ph.D.
- Graduate student, 2013 – 2018
- Shanrong Shu, M.D.
- Visiting Professor, 2018 – 2019
- Current position: Professor, Jinan University
- Nathaniel Hwang, Ph.D.
- Visiting Professor, 2018 – 2019
- Current position: Professor, Seoul National University
- Hu Xiong, Ph.D.
- Postdoc, 2014 – 2018
- Current position: Professor, Nankai University
- Kejin Zhou, Ph.D.
- Postdoc, Instructor, 2012 – 2020
- Former position: Principal Scientist, Poseida Therapeutics
- Current position:
- Melissa Coquelin
- Former position: ReCode Therapeutics
- Current position:
- Martha Marquez Ramirez
- SURF student / Amgen Scholar, 2019
- Former position: Undergraduate student, University of California, Berkeley
- Current position: Graduate student, San Francisco State University
- Tina Lin
- Green Fellow, 2020
- Former position: Undergraduate student, University of Texas at Dallas
- Current position: Graduate student, Carnegie Mellon University
- Domenico Orlando, Ph.D.
- Postdoc, 2019 – 2020
- Current position: DiaSorin
- Rhapsede Nolden
- Research Technician, 2019 – 2020
- Current position: Undergraduate student, Texas A&M
- Xueliang Yu, Ph.D.
- Postdoc, 2018 – 2020
- Current position:
- Junyu Gong, Ph.D.
- Postdoc, 2020
- Current position: ReCode Therapeutics
- Tuo Wei, Ph.D.
- Postdoc, 2017 – 2021
- Current position: Professor, Chinese Academy of Sciences, Institute of Zoology, Beijing
- Qiang Cheng, Ph.D.
- Postdoc, 2017 – 2021
- Current position: Professor, Peking University
- Shuai Liu, Ph.D.
- Postdoc, 2017 – 2021
- Current position: Professor, Zhejiang University
- Madeline Brown
- SURF student / Amgen Scholar, 2022
- Current position: Undergraduate student, University of California, San Diego
- Sang Lee, Ph.D
- Graduate student, 2017 – 2022
- Current position: Sanofi
- Lindsay Johnson, Ph.D.
- Graduate student, 2017 – 2022
- Current position: Gilead
- Di Zhang, Ph.D.
- Postdoc, 2019 – 2023
- Current position: AskBio
- Sean Dilliard, Ph.D.
- Graduate student, 2018 – 2023
- Current position: Prime Medicine
- Ester Alvarez Benedicto, Ph.D.
- Graduate student, 2018 – 2023
- Current position: Metagenomi
- Yangyang Yang, Ph.D.
- Postdoc, 2023 – 2023
- Current position: Professor, Shanghai Jiao Tong University
- Isaac Quinonez
- Green Fellow, 2023
- Current position: Undergraduate student, University of Texas at Dallas
